CASE REPORT

JOP. J Pancreas (Online) 2005; 6(4):339-343.

Surgical Treatment of Pancreatic Metastases of Renal Cell Carcinoma

Georgios C Sotiropoulos1, Hauke Lang1, Chao Liu2, Eirini I Brokalaki1, Ernesto Molmenti1, Christoph E Broelsch1

1Department of General Surgery and Transplantation, University Hospital Essen. Essen, Germany. 2Department of General Surgery, Medical College, Sun Yat-sen University. Guangzhou, China

ABSTRACT

Context The pancreas is an unusual site for metastases of renal cell carcinoma origin, sometimes occurring many years after nephrectomy. We herein present two cases of pancreatic metastases of renal cell carcinoma which occurred 17 and 19 years after the primary diagnosis.

Case report In the first case, metastases were found in the head of the pancreas, upper right arm and the right lobe of the thyroid gland. In the second case, a tumor was found in the tail of the pancreas and a remnant of the right kidney. This was the third recurrence of the original tumor after an initial left nephrectomy and two subsequent partial right nephrectomies in the past. Treatment in the first case consisted of excision of the tumor in the upper right arm, a Whipple operation, and a thyroidectomy. In the second case, a distal pancreatectomy and remnant right nephrectomy were undertaken. Both patients recovered from the operations without complications and remain free of tumor in follow-up periods of 54 and 8 months respectively.

Conclusions Resection of renal cell carcinoma metastases involving the pancreas provides satisfactory long-term survival, and should be undertaken whenever possible.

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References

  1. Roland CF, van Heerden JA. Nonpancreatic primary tumors with metastases to the pancreas. Surg Gynecol Obstet 1989; 168:345-7. [More details]

  2. Thompson LD, Heffess CS. Renal cell carcinoma to the pancreas in surgical pathology material. Cancer 2000; 89:1076-88. [More details]

  3. Faure JP, Tuech JJ, Richer JP, Pessaux P, Arnaud JP, Carretier M. Pancreatic metastasis of renal cell carcinoma: presentation, treatment and survival. J Urol 2001; 165:20-2. [More details]

  4. McNichols DW, Segura JW, DeWeerd JH. Renal cell carcinoma: long-term survival and late recurrence. J Urol 1981; 126:17-23. [More details]

  5. Robbins EG 2nd, Franceschi D, Barkin JS. Solitary metastatic tumors to the pancreas: a case report and review of the literature. Am J Gastroenterol 1996; 91:2414-7. [More details]

  6. Sohn TA, Yeo CJ, Cameron JL, Nakeeb A, Lillemoe KD. Renal cell carcinoma metastatic to the pancreas: results of surgical management. J Gastrointest Surg 2001; 5:346-51. [More details]

  7. Temellini F, Bavosi M, Lamarra M, Quagliarini P, Giuliani F. Pancreatic metastasis 25 years after nephrectomy for renal cancer. Tumori 1989; 75:503-4. [More details]

  8. Ghavamian R, Klein KA, Stephens DH, Welch TJ, LeRoy AJ, Richardson RL, et al. Renal cell carcinoma metastatic to the pancreas: clinical and radiological features. Mayo Clin Proc 2000; 75:581-5. [More details]

  9. Kassabian A, Stein J, Jabbour N, Parsa K, Skinner D, Parekh D, et al. Renal cell carcinoma metastatic to the pancreas: a single-institution series and review of the literature. Urology 2000; 56:211-5. [More details]

  10. Moutardier V, Berthet B, Le Treut Y. Pancreatic metastasis of a Grawitz tumor. J Chir (Paris) 1993; 130:439-40. [More details]

  11. Altschuler EL, Ray A. Spontaneous regression of a pancreatic metastasis of a renal cell carcinoma. Arch Fam Med 1998; 7:516-7. [More details]

  12. Gohji K, Matsumoto O, Kamidono S. Solitary pancreatic metastasis from renal cell carcinoma. Hinyokika Kiyo 1990; 36:677-81. [More details]

  13. van der Poel HG, Roukema JA, Horenblas S, van Geel AN, Debruyne FM. Metastasectomy in renal cell carcinoma: A multicenter retrospective analysis. Eur Urol 1999; 35:197-203. [More details]

  14. Kavolius JP, Mastorakos DP, Pavlovich C, Russo P, Burt ME, Brady MS. Resection of metastatic renal cell carcinoma. J Clin Oncol 1998; 16:2261-6. [More details]

  15. Carini M, Selli C, Barbanti G, Bianchi S, Muraro G. Pancreatic late recurrence of bilateral renal cell carcinoma after conservative surgery. Eur Urol 1988; 14:258-60. [More details]

  16. Bassi C, Butturini G, Falconi M, Sargenti M, Mantovani W, Pederzoli P. High recurrence rate after atypical resection for pancreatic metastases from renal cell carcinoma. Br J Surg 2003; 90:555-9. [More details]

  17. Hashimoto M, Watanabe G, Matsuda M, Dohi T, Tsurumaru M. Management of the pancreatic metastases from renal cell carcinoma: report of four resected cases. Hepatogastroenterology 1998; 45:1150-4. [More details]

  18. Kierney PC, van Heerden JA, Segura JW, Weaver AL. Surgeon’s role in the management of solitary renal cell carcinoma metastases occurring subsequent to initial curative nephrectomy: an institutional review. Ann Surg Oncol 1994; 1:345-52. [More details]

  19. Tuech JJ, Pessaux P, Chautard D, Rouge C, Binelli C, Bergamaschi R, Arnaud JP. Results of duodenopancreatectomy for solitary pancreatic metastasis from renal cell carcinoma. J Hepatobiliary Pancreat Surg 1999; 6:396-8. [More details]

  20. Law CH, Wei AC, Hanna SS, Al-Zahrani M, Taylor BR, Greig PD, et al. Pancreatic resection for metastatic renal cell carcinoma: presentation, treatment, and outcome. Ann Surg Oncol 2003; 10:922-6. [More details]

Keywords Carcinoma, Renal Cell; Neoplasm Metastasis; Pancreatectomy; Pancreatic Diseases

Correspondence Georgios C Sotiropoulos: georgios.sotiropoulos@uni-essen.de