CASE REPORT

JOP. J Pancreas (Online) 2004; 5(5):384-387.

Coxsackievirus Infection Associated with Acute Pancreatitis

George Chrysos1, Stelios Kokkoris1, John Protopsaltis1, Panagiotis Korantzopoulos2, Gregory Giannoulis1

1Second Department of Internal Medicine, "Tzanio" General Hospital of Piraeus. Piraeus, Greece. 2Department of Internal Medicine, "G. Hatzikosta" General Hospital of Ioannina. Ioannina, Greece

ABSTRACT

Context A variety of infectious agents have been reported as rare causes of acute pancreatitis.

Case report We briefly describe a 36-year-old man who presented with acute pancreatitis and a maculopapular rash. The marked elevation in antibody titer against coxsackievirus B, as well as the skin biopsy, was compatible with acute coxsackievirus B viral infection.

Conclusion This case highlights the fact that an appropriate investigation for viral infections should be performed in patients having acute pancreatitis and no classical risk factors.

Full text: HTML format  PDF format
  Look up who cited this article

References

  1. Parenti DM, Steinberg W, Kang P. Infectious causes of acute pancreatitis. Pancreas 1996; 13:356-71. [More details]

  2. Dalldorf G, Sickles GM. An unidentified, filtrable agent isolated from the feces of children with paralysis. Science 1948; 108:61-2. [More details]

  3. Rueckert RR. Picornaviridae: the viruses and their replication. In: Fields BN, Knipe DM & Howley PM, eds. Fundamental Virology. 3rd ed. Philadelphia, USA: Lippincott-Raven Publishers, 1996:477-522. [More details]

  4. Coplan NL, Atallah V, Mediratta S, Bruno MS, DePasquale NP. Cardiac, pancreatic, and liver abnormalities in a patient with coxsackie-B infection. Am J Med 1996; 101:325-6. [More details]

  5. Lau G. Acute fulminant, fatal coxsackie B virus infection: a report of two cases. Ann Acad Med Singapore 1994; 23:917-20. [More details]

  6. Grist NR, Bell EJ, Assaad F. Enteroviruses in human disease. Prog Med Virol 1978; 24:114-57. [More details]

  7. Melnick JL. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses. In: Fields BN, Knipe DM, Chanock RM, Melnick JL, Roizman B, Shope RE, eds. Virology. New York, NY, USA: Raven Press, 1985:739-94. [More details]

  8. Tracy S, Chapman NM, Romero J, Ramsingh AI. Genetics of coxsackievirus B cardiovirulence and inflammatory heart muscle disease. Trends Microbiol 1996; 4:175-9. [More details]

  9. Ramsingh AI, Chapman NM, Tracy S. Coxsackieviruses and diabetes. Bioessays 1997; 19:793-800. [More details]

  10. Melnick JL. Enteroviruses: polioviruses, coxsackieviruses, echoviruses, and newer enteroviruses. In: Fields BN, Knipe DM, Howley PM, eds. Fields Virology. Philadelphia, Lippincott-Raven Publishers, 1996:655-705. [More details]

  11. Gooby Toedt DM, Byrd JC, Omori D. Coxsackievirus-associated pancreatitis mimicking metastatic carcinoma. South Med J 1996; 89:441-3. [More details]

  12. Lal SM, Fowler D, Losasso CJ, Berg GG. Coxsackie virus-induced acute pancreatitis in a long-term dialysis patient. Am J Kidney Dis 1988; 11:434-6. [More details]

  13. Kennedy JD, Talbot IC, Tanner MS. Severe pancreatitis and fatty liver progressing to cirrhosis associated with Coxsackie B4 infection in a three year old with alpha-1-antitrypsin deficiency. Acta Paediatr Scand 1986; 75:336-9. [More details]

  14. Lankisch PG, Burchard-Reckert S, Petersen M, Lehnick D, Schirren CA, Kohler H, et al. Morbidity and mortality in 602 patients with acute pancreatitis seen between the years 1980-1994. Z Gastroenterol 1996; 34:371-7. [More details]

  15. Lankisch PG, Schirren CA, Kunze E. Undetected fatal acute pancreatitis: why is the disease so frequently overlooked? Am J Gastroenterol 1991; 86:322-6. [More details]

  16. Kibrick S, Benirschke K. Severe generalized disease (encephalohepatomyocarditis) occurring in newborn period and due to infection with coxsackievirus, group B. Pediatrics 1958; 22:857-75. [More details]

  17. Imrie CW, Ferguson JC, Sommerville RG. Coxsackie and mumpsvirus infection in a prospective study of acute pancreatitis. Gut 1977; 18:53-6. [More details]

  18. Capner P, Lendrum R, Jeffries DJ, Walker G. Viral antibody studies in pancreatic disease. Gut 1975; 16:886-70. [More details]

  19. Arnesjo B, Eden T, Ihse I, Nordenfelt E, Ursing B. Enterovirus infections in acute pancreatitis. A possible etiological connection. Scand J Gastroenterol 1976; 11:645-9. [More details]

  20. Ozsvar Z, Deak J, Pap A. Possible role of coxsackie-B virus infection in pancreatitis. Int J Pancreatol 1992; 11:105-8. [More details]

  21. Laszik ZG, Kallajoki M, Hyypia T, Rima B, Aho HJ, Nevalainen TJ. Mumps, enteroviruses, and human acute pancreatitis. Scand J Gastroenterol 1990; 25:906-10. [More details]

  22. Marum S, Veiga MZ, Silva F, Vasconcelos T, Ferreira A, Viegas J. Lupus pancreatitis. Acta Med Port 1998; 11:779-82. [More details]

  23. Corey L. Rabies, rhabdoviruses and Marburg-like agents: Marburg virus disease. In: Isselbacher K, Braunwald E, Wilson J, Martin J, Fauci A, Kasper D, eds. Harrison’s Principles of Internal Medicine. 13th ed. New York, NY, USA: McGraw-Hill Co., 1994:835-6. [More details]

  24. Petersen LR, Marfin A. West Nile Virus: A Primer for the clinician. Ann Intern Med 2002; 137:173-9. [More details]

  25. Fields C, Robinson J, Roy T, Ossorio MA, Byrd RP Jr. Hypersensitivity reaction to azathioprine. S Med J 1998; 91:471-4. [More details]

  26. Pau AK. Antiretroviral therapy-associated serious and life-threatening toxicities. Curr Infect Dis Rep 2003; 5:429-38. [More details]

Keywords Coxsackievirus B; Exanthema; Pancreatitis; Virus Diseases

Correspondence Stelios Kokkoris: skokkoris2003@yahoo.gr